DAA, PPAR + MCP-1

After reading 'Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of MCP-1 from adipocytes' article, i found another article that talks about a substance inhibiting MCP-1 activity. Dehydroabietic acid (DAA) is an abietic acid derivative contained in Terpenoids of many herbal and dietary plant substances. An experiment done by M-S Kang et al showed that DAA acts as an agonist of PPARs (peroxisome proliferator-activated receptors), which is a ligand-activated nuclear transcription factor that regulate lipid metabolism and homeostasis. PPAR-gamma subtypes has been shown to mediate anti-inflammatory effects on macrophages once it is activated so if DAA stimulates PPAR-gamma subtypes release by binding to its receptor then it can induce anti-inflammatory response on macrophages thereby inhibiting the pro-inflammatory cytokine release from macrophages. From their experiment, they found that DAA does indeed inhibit the production of pro-inflammatory cytokines (TNF-alpha) and chemokine (MCP-1). Since DAA activates PPAR, which is important on lipid metabolism and homeostasis, its a valuable medicinal and food component for regulating the inflammatory changes in obese individual.



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