As we read in this weeks articles, interleukin 10 (IL10) is an anti-inflammatory cytokine that helps reduce the damage caused by inflammation after a stroke. I did more research on this cytokine and found in the paper, Interleukin-10 Modulates Neuronal Threshold of Vulnerability to Ischaemic Damage, that the source of IL-10 in the brain is activated microglia. This superised me, because last week we read in the article, The Inflammatory Response in Stroke, that activated microglia may contribute to brain injury during a stroke. The paper does not detail the mechanism or outline a possible mechanism about how IL-10 gets released from activated microglia and I was unable to find more papers on this in a Pubmed search, but it is interesting information.
http://www.blackwell-synergy.com.ezproxy1.library.arizona.edu/doi/abs/10.1046/j.1460-9568.2000.00090.x
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In a recent study, they did a genotype distribution analysis in which they found that the frequency of the genotype (-1082GG) was associated with the increased production of interleukin 10 and the frequency of genotype (-1082AA) was associated with lower production of IL10.
Researchers studied the genotype for IL 10 -1082/-819/-592 to determine if IL 10 genotype has a component of genetic backgroud that is protective against
CV disease.
They studied two cohorts of italian men The first group comprised of 142 patients affected by acute MI (age 55-80)and 153 healthy controls (age 65-73). The second cohort included 90 subjects (age 23-46) affected with acute MI and 110 healthy controls (age 20-55). They also had another control group of men over the age of 95. In their results, young and old patients with coronary heart disease had the genotype -1082AA being overrepresented and healthier subjects had the genotype -1088GG overexpressed.
Lower plasma levels of IL10 were seen in subjects with less stable form of angina then the stable ones so they determined the genotype (-1082AA) that produced lower IL10 responsible for inflamation response and also increased risk for inflamatory disease.
They also found that patients who tested positive for CRP and had high IL10 plasma levels were less likely to be at risk for CV than patients with CRP with low levels of IL-10.
According to the study, people who have a longer life spand posses genetic factors that regulates their ageing processes as well as protect them from cardiovascular disease factors. They seem to think that the genotype 1082GG is associated with the increased lifespan.
Pretty interesting article.
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