Here is the passage i read at the end of our last discussion...
"Interleukin-6 (IL-6) could mediate some of the health beneficial effects of exercise. In resting muscle, the IL-6 gene is silent, but it is rapidly activated by contractions. The transcription rate is very fast and the fold changes of IL-6 mRNA is marked. IL-6 is released from working muscles into the circulation in high amounts. The IL-6 production is modulated by the glycogen content in muscles, and IL-6 thus works as an energy sensor. IL-6 exerts its effect on adipose tissue, inducing lipolysis and gene transcription in abdominal subcutaneous fat and increases whole body lipid oxidation. Furthermore, IL-6 inhibits low-grade TNF-a-production and may thereby inhibit TNF-a-induced insulin resistance and atherosclerosis development."
As we've investigated the causes of diabetes mellitus, obesity, and the resulting atherosclerosis over the last two weeks, every article has listed IL-6 as a statistically significant factor to these inflammation related health problems. With this study were seeing a different perspective on ways to regulate IL-6 in the body through exercise. Muscle-derived IL-6 is shown to be a strong mediator of the anti-inflammatory effects of exercise, and to have beneficial health effects on vascular compartments. The first thing that i thought upon reading this, is that lap band surgery really can be avoided if these results are true, and that diet and exercise to a large degree can offer protection against cardiovascular disease , type 2 diabetes, ischemic heart disease, heart failure, athersclerosis, blood pressure and obesity. What is everyone's response to this contradiction between the importance and effects of muscle derived IL-6 versus elevated IL-6 in adipose tissue?
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http://www.springerlink.com/content/j4501nj643464268/fulltext.pdf
sorry, forgot to include the article for everyone to look over.
Heres another very interesting article on IL-6 regarding its effects on weight loss and more importantly weight RE-gain, due to the induced inflammation in adipocytes from exercise (also contradictory). So while the level of IL-6 in your body may not effect your ability to lose weight, it does play a major role in how difficult it is to keep that weight from comming back. So according to the study, high amounts of exercise can put you at risk for weight gain (especially after losing weight), and that keeping IL-6 levels low should be a concern.
http://journals.cambridge.org/download.php?file=%2FBJN%2FBJN96_05%2FS0007114506003199a.pdf&code=9143a32c34b1a7c03e3ad43a422129d3
sorry, heres the second article
While I was trying to understand the difference between impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), I came across this very interesting article that not only defines these terms but also describes how these two conditions progress into Type II diabetes and can also lead to cardiovascular diseases. It also stated that exercise or as they refer to it "lifestyle intervention", even though difficult to implement, has been proven to be "superior to drug therapy". Exercise has been proven to reduce the risk of type II diabetes, cardiovascular diseases, as well as other diseases. In the studies presented, participants were recommended to exercise a minimum of 150 minutes a week. The results of the studies showed a 46-58% risk reduction in the incidence of diabetes. The article states that pharmacological agents should be discourage as substitutes for healthier lifestyle changes.
Great article! Here is the website and I hope you all enjoy it as much as I did.
IFG & IGT
http://www.aafp.org/afp/20040415/1961.html
Journal of American Academy of Family Physicians
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