23 September 2007

Do Vaccines Cause Autism?

For about the last decade, a debate has been raging between researchers, health professionals, parents, and the government about whether vaccines cause autism. Autism is a developmental disability that causes impairments with social interaction and communication, and also marked by unusual or repetitive behaviors and interest. Children are usually diagnosed around ages two to four, when social interaction becomes more complex and children start preschool. There is no laboratory test for autism – it is diagnosed by observation, interaction, and psychological tests.

Statistics differ slightly, but in the 1970s approximately 1 in 10,000 children was diagnosed with autism. Today, about 1 in 500 children is diagnosed with autism.

The causes for autism are complex. Autism has been shown to have both genetic and environmental components. The apparent rise in autism rates have led some to suspect vaccines may be the cause, in particular the MMR (measles, mumps, and rubella) vaccine. Parents report that an otherwise normally developing baby or toddler suddenly shows the signs of autism 1-2 months after receiving a vaccine. Vaccines contain mercury and other substances known to cause neurological defects. In fact, the ingredient list for a vaccine is downright scary. Parents are very worried that something which is designed to protect the health of their child is instead causing developmental problems.

Despite this anecdotal evidence, careful studies by the Centers for Disease Control and Prevention and the National Institutes of Health have failed to identify a causal link between vaccines and autism. Studies concluding a direct causal relationship have failed to include sufficient controls or haven’t blinded researchers making judgment calls. Vaccination rates have not increased with the pace of autism rates; there must be some other factor(s) at work. For one, we are now more aware of autism as a disease and children are often diagnosed at a younger age. Perhaps in the 1970s many children with less severe symptoms were never diagnosed. Also, over the past 30 years, Americans’ diets have changed drastically to include more preservatives, dyes, artificial ingredients, saturated fats, etc. More young children do not meet the minimum requirements for consumption of fruits, vegetables, and vitamins. Eating habits have changed on pace with autism rates. Perhaps diet should be investigated as a cause of autism?

In the meantime, we can’t afford to take chances with vaccines. Vaccine companies have reformulated their products without the use of toxic ingredients. Parents can vaccinate their children without concern about autism. Unfortunately, some parents are not getting the message that vaccines have been shown to be safe, despite all the controversy. We need to do a better job of getting this information out to the lay community. In fact, the Sept. 18th episode of Oprah featured Jenny McCarthy, who blamed her child's autism on vaccines. The general public may be more inclined to believe this hype over careful research, which doesn't make the headlines.

References: Centers for Disease Control and Prevention website: "Autism and Vaccines Theory"; Institute of Medicine of the National Academies website: "Immunization Safety Review: Vaccines and Autism"; "Vaccines and Autism" article by Dr. Paul Offit of the Vaccine Education Center, Children's Hospital of Philadelphia published by the Immunization Action Coalition

12 comments:

NathanS495 said...

This is a rather interesting point that you bring up. There is a lot of stuff in vaccines that is "scary". If there is a correlation between autism and vaccines amongst babies and children, vaccines should be further investigated into. It would be interesting to read up on some studies about autism and vaccines.

Lauren7630 said...

The idea that some vaccines, to be more specific the mercury within the vaccines, causes autism has been a concern within the pediatric field for some time. Within the last 5 years or more mercury has been removed from all vaccines except a few influenza vaccine (which are in the process of being removed). However, with mercury removed from vaccines, autism is still on the rise. There has been 10 epidemiologic studies that fail to see a correlation between ethylmercury (mercury within vaccines) and autism. Two pharmacokinetic studies identified that ethylmercury has a shorter half life than the mercury one ingests from fish. This data suggests that there is an alternative cause for autism. If you want more information please see the review article referenced below.

Parker SK, et al. Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data. Pediatrics. 2004 114(3):793-804.

BrandyL7630 said...

You noted that parents often first see signs of autism 1-2 months after the vaccine is given. MMR is first given at 1 year of age and as a booster shot at 5 years of age. Not coincidentally, important developmental milestones develop around 14 months of age, such as learning specific words, playing with other children, and becoming aware of the concept of “self”. When these milestones are delayed as in autism, of course people will look for “causes” and vaccines have become such easy targets. There are many confounding factors that contribute to autism and as Lauren7630 stated, there have been numerous epidemiologic studies that have shown no association of vaccines with autism. As a pediatrician, I have seen too many children suffer serious morbidity and mortality from diseases that vaccines prevent. I agree that parents should not have to worry about “poisoning” their children; however, vaccines today are safe and go through rigorous testing.

DavidM495 said...

you must answer the question, do the benefits outweight the costs?

TressaA said...

To several of you who left comments, I'm not saying that vaccines cause autism. I'm saying that parents need to be put at ease. Parents are apparently unaware of these epidemiological studies that show that vaccines are safe. In fact, I know some parents who've chosen not to vaccinate their kids because of this belief, which is very sad and a huge risk to the children. The scientific community is reassured that vaccines are safe, but until parents are convinced we need to do a better job of getting the results of these studies out to the lay community.

TeriH7630 said...

Interesting discussion... naturally I have thought about this issue every time I have had my 3 girls vaccinated. At one point, Colorado ranked very low in immunization rates. I just looked up the recent data, and in the year 2006, complete immunization of children ages 19 to 35 months increased from 77.1 percent to 83.4 percent (http://www.cdphe.state.co.us/release/2006/120506.html). That is good news. TLH

JJ Cohen said...

This is very timely: The New England Journal of Medicine today published the largest study ever on whether there is a link between thimerosal mercury in vaccines and any neurological outcome years later. From the paper: Conclusions: Our study does not support a causal association between early exposure to mercury from thimerosal-containing vaccines and immune globulins and deficits in neuropsychological functioning at the age of 7 to 10 years.
In an editorial, it is pointed out that well-meaning people at CDC and from the American Pediatrics Association, wishing to be seen as responding to concerns, recommended in 1999 that mercury be removed from all vaccines immediately. Instead of calming parents, this statement triggered a panic, which we are still living with in some ways.

JennaL7630 said...

The scientific term of relating the increase in autism rates with the increasing number of vaccines given to children is "ecological fallacy". From Wikipedia, "The ecological fallacy is a widely recognized error in the interpretation of statistical data, whereby inferences about the nature of individuals are based solely upon aggregate statistics collected for the group to which those individuals belong." Of course, the lay public doesn't understand this type of error, but scientifically, these misconceptions should remind us to design epidemiologic studies at the individual level, as the one JJC7630 has mentioned.

stephenb7630 said...

The benefits easily outweigh any perceived risks. Please get your kids vaccinated so we can get percentages up for herd immunity. I want to reduce the risk for the kids who have parents that are mis-informed about vaccines.

JanH7630 said...

In response to JJC7630 on 9/27, have there been follow-up studies to this policy change/recommendation in 1999 of mercury removal? I'd be interested in the association between vaccines and autism once mercury was removed. It appears as though the public WILL NOT be convinced that this association between autism and vaccines does not exist unless actual components of the vaccine are evaluated.

Nice job, JennaL7630.

JennyP7630 said...

Very interesting post... it seems like people keep speculating what brings on autism... whether it's vaccines or watching TV at an early age. I've spoken with a few of my friends and we've concluded that we think autism is the next step in human evolution. Some of these people who are autistic have amazing abilities... Autism is also subdivided into several different classes. Does the paper suggest what kind of autisim is supposedly caused by vaccinations?

KomalN7630 said...

The first aricle linking MMR vaccination with autism by Wakefield et al. was first published in Lancet in 1998. Dr. Wakefield based this study on 12 patients with autism who had been referred to him for gastrointestinal disorder evaluation. On obtaining vaccination histories, he found that the onset of disease had occured within 2 weeks after MMR vaccination. He also noted that the incidence of autism had increased in the UK after the introduction of MMR vaccine. Dr. Wakefield assumed temporal relationship to be a causal relationship (temporal relation is just one of the many criteria in establishing causality)and had misinterpreted ecological data. Despite strong contrary evidence to Dr. Wakefield's study, the controversy surrounding the purported causal association, has had detrimental impact on people.

One more article defending childhood vaccination:
On October 27, the Wall Street Journal published an interesting guest editorial, "The New McCarthyism: Vaccines & Autism" that defends childhood vaccination.

Ref: Wakefield, A (02/28/1998). "Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.". The Lancet (British edition) (0140-6736), 351 (9103), p. 637